2 TERT BUTYL 7 CHLORO 3 IODO 5 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 2R 6R 2 6 Diethyl piperazine 5 HYDROXY 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 7 METHOXY 2 5 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2 5 7 TRIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2 METHYL 7 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 7 HYDROXY 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2 METHOXYMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2R 6R 2 6 Dimethyl piperazine 2HCl 2 Hydrazinyl 6 methylpyridine 7 PYRIDIN 3 YL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 3 Bis benzyl amino hexahydro 2H azepin 2 one 2 PHENYL PYRAZOLO 1 5 A PYRIMIDIN 5 OL 4 2 PHENYL 5 7 BIS TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDIN 3 YL PHENOL 2S 6S 2 6 Dimethylmorpholine 4 Benzylmorpholin 2 yl methylamine 7 FURAN 2 YL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 4 4 Boc piperazin 1 yl 3 trifluoromethylaniline 6 METHYL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBOXYLIC ACID 1 2 3 5 6 7 HEXAHYDRO 4 8A 9 TRIAZA CYCLOPENTA A S INDACEN 8 YLAMINE 3 3 4 DIETHOXY PHENYL 6 4 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 2 Piperazin 1 yl benzoic acid methyl ester 6 4 METHOXY PHENYL 3 THIOPHEN 2 YL PYRAZOLO 1 5 A PYRIMIDINE 3 2 4 DIMETHYLAMINO PHENYL PYRAZOLO 1 5 A PYRIMIDIN 6 YL PROPAN 1 OL 7 AMINOPYRAZOLO 1 5 A PYRIMIDINE 6 CARBONITRILE 5 METHYL 2 PHENYL PYRAZOLO 1 5 A PYRIMIDIN 7 OL 4 7 Diaza spiro 2 5 octane 4 carboxylic acid tert butyl ester 2R 3 4 Dihydro 2H 1 benzopyrane 2 methylamine hydrochloride 3 4 Boc piperazin 1 yl aniline 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 5 7 DIOL

6 BROMO 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 5 7 DICHLORO 3 METHYLPYRAZOLO 1 5 A PYRIMIDINE 3 4 FLUOROPHENYL 2 7 DIMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 3 Isopropylmorpholine 3 Ethylmorpholine 2 Methyl 1 5 pentanediol 1 quinolin 2 yl ethanone 4 bromo 2 methoxythiazole 5 bromo 2 methoxythiazole 10H Phenoxazine 10 ethanol 2 4 chlorophenylamino 4 9 dioxo 4 9 dihydronaphtho 2 3 b thiophene 3 carboxylic acid 5 Hydroxymethyl dihydrofuran 2 3H one 4 bromo 2 isopropylthiazole 3 3 5 Di tert butyl 4 hydroxy phenyl 2 2 dimethylpropanol 1R 4aR 4bS 10aR methyl 2 4b 8 8 10a pentamethyl 1 4 4a 4b 5 6 7 8 8a 9 10 10a dodecahydrophenanthrene 1 carboxylate 6 hydroxy 9H purine 3 N oxide 6E 10E tricosa 6 10 dien 1 ol 2 chloro N 2 chloroethyl N cyclopropylmethyl ethanamine hydrochloride 8 Methyl 8 azabicyclo 3 3 1 oct 6 en 3 ol HCl 1R 5S tert Butyl 3 trifluoromethylsulfonyloxy 8 azabicyclo 3 2 1 oct 2 ene 8 carboxylate 4R 1 Boc 4 hydroxy azepane 2 2 2 diethoxyethoxy 1 1 diethoxyethane 4S 1 Boc 4 hydroxy azepane 1 1 Bis hydroxymethyl cyclopropane 1S 2R 1 Phenyl 2 1 pyrrolidinyl 1 propanol 3 4 4 5 5 tetramethyl 1 3 2 dioxaborolan 2 yl cyclopentanone 2 2 4 dimethylphenyl 1 2 dihydropyrazol 3 one 5 6 7 trimethoxy 2 phenylquinolin 4 1H one 5 Hydroxymethyl morpholin 3 one 4 1 Amino ethyl benzoic acid

2 aminobenzoic 3 4 dimethoxybenzoic anhydride 4 4 1E 1 E 2 2 1 phenyl 1H pyrazole 3 5 diyl bis ethene 2 1 diyl bis 2 methoxyphenol 2 methylpentanedioic acid 2 2 4 dimethylphenyl phthalazin 1 2H one 1 2 4 dimethylphenyl 2 3 methoxyphenyl diazene 1 Methyl 1 2 3 4 Tetrahydroisoquinoline 8 carboxylic acid 1 benzhydryl 3 3 difluoroazetidine 1 benzhydrylamino 3 chloropropan 2 ol 2 Benzyl 1 2 3 4 tetrahydroisoquinoline 8 carboxylic acid 1 8 diazaspiro 5 5 undecan 7 one 1R 3S 3 tert Butoxycarbonylamino cyclohexanecarboxylic acid 1 Propanone 1 2 4 difluorophenyl 2 hydroxy 2R 1 Benzyl pyrrolidine 3 4 dicarboxylic acid 1 oxa 3 9 diazaspiro 5 5 undecan 2 one hydrochloride 8 methoxycarbonyl octanoic acid 2 Oxo 3 piperidinecarboxylic acid 1 Boc 1 2 5 6 tetrahydropyridine 3 carboxylic acid 2 methylpiperidine 2 carboxylic acid hydrochloride 2 OXA SPIRO 3 3 HEPTAN 6 ONE 2R 4S 1 tert Butoxycarbonyl 4 fluoropyrrolidine 2 carboxylic acid 1R 3R trans 3 Hydroxy cyclopentanecarboxylic acid 1R 3S cis 3 Hydroxy cyclopentanecarboxylic acid 3 fluorotetrahydro 2H pyran 4 yl methanesulfonate 1S 3R 3 Hydroxycyclopentanecarboxylic acid 1S 3S 3 Hydroxycyclopentanecarboxylic acid 1R 3R 3 Hydroxycyclopentanecarboxylic acid 3 Hydroxy cyclopentanecarboxylic acid 2 1 ADAMANTANYL ETHYL ACETATE 2 2S 5 Oxooxolan 2 yl acetic acid 2 5 Oxooxolan 2 yl acetic acid

4 2 Oxo 2 2 oxo 4 R phenyl oxazolidin 3 yl ethyl piperidine 1 carboxylic acid tert butyl ester 2 2R 5 oxooxolan 2 yl acetic acid 4 methylsulfonyl 2 trifluoromethyl benzaldehyde 3 Amino 1 1 3 propanetricarboxylic cid 1 bromomethyl 2 trifluoromethyl 4 methylsulfonyl benzene 1R 3R 3 aminocyclohexane 1 carboxylic acid 1S 3S 3 aminocyclohexane 1 carboxylic acid 5 hydroxy 5 trifluoromethyl dihydrofuran 2 3H one 4 4 difluoro N S 3 1S 3R 5R 2 fluoro 3 3 isopropyl 5 methyl 4H 1 2 4 triazol 4 yl 8 aza bicyclo 3 2 1 octan 8 yl 1 phenylpropyl adamantanecarboxamide 3 3 difluoro N S 3 1S 3R 5R 3 3 isopropyl 5 methyl 4H 1 2 4 triazol 4 yl 8 aza bicyclo 3 2 1 octan 8 yl 1 phenylpropyl piperidine 4 carboxamide 2R 3 Amino 2 hydroxy propanoic acid 2 Oxetan 2 yl acetic acid ethyl ester 4 Bromo 2 5 difluorobenzoic acid 5 Cyclopropyl 1H pyrazol 3 amine hydrochloride 1 6 Trifluoromethyl pyridin 3 yl ethanone 1 Piperidin 4 yl piperidine 4 carboxylic acid Hydrochloride 2 Trifluoromethyl pyrimidine 4 carboxylic acid 4 Bromo 7 methoxy 1H indole 1 1 Boc piperidin 4 yl piperidine 4 carboxylic acid 1S 3R 3 Amino cyclohexanecarboxylic acid 1 Methylcyclopropanamine hydrochloride 3 5 Difluoro 4 nitrobenzonitrile 1R 3S 3 Amino cyclohexanecarboxylic acid 3 5 Dibromo 4 methoxypyridine 4 Vinylsulfonylbenzoicacid 1S 3S N Boc 3 Aminocyclopentanecarboxylic acid 2 4 Bromo 3 fluorophenyl acetonitrile 1R 3S N Boc 3 Aminocyclopentanecarboxylic acid 1S 3R N Boc 3 Aminocyclopentanecarboxylic acid 4 5 6 7 Tetrahydro 1H benzo d imidazole 5 carboxylic acid hydrochloride