1 ethyl 5 4 4 5 5 tetramethyl 1 3 2 dioxaborolan 2 yl 1 2 3 6 tetrahydropyridine 1 benzyl 3 5 dimethyl piperidine 1 3 5 tricarboxylate 8 Boc 2 8 DIAZA SPIRO 5 5 UNDECAN 1 ONE 7 Boc 2 7 DIAZA SPIRO 5 5 UNDECAN 1 ONE 1 tert butylpiperidin 4 one 8 Boc 2 8 DIAZA SPIRO 5 4 DECAN 1 ONE 10 10 DIFLUORO 2 7 DIAZA SPIRO 4 5 DECAN 1 ONE HYDROCHLORIDE 2S 1 tert butoxycarbonyl 4 hydroxypiperidine 2 carboxylic acid 1 tert butoxycarbonyl 2 methoxycarbonyl piperidine 4 carboxylic acid 4 5 6 7 tetrahydro 1H pyrazolo 3 4 c pyridin 3 ol hydrochloride 2 N methyl 1 HYDROXYMETHYL 2 AZABICYCLO 2 2 2 OCTANE 1 HYDROXYMETHYL 2 AZABICYCLO 2 2 2 OCTANE 1 tert butoxycarbonyl octahydro 1H pyrrolo 3 2 c pyridine 3a carboxylic acid 1 2 bis 1 benzylpiperidin 4 ylidene hydrazine 4 bromomethyl piperidine hydrochloride 3 OXO 2 AZABICYCLO 2 2 2 OCTANE 1 CARBOXYLIC ACID METHYL ESTER 7 N BENZYL 1 OXO 2 7 DIAZA SPIRO 4 5 DECAN 10 ONE ETHYLENE KETAL 1 tert butyl 3 3 dimethyl 4 oxopiperidine 1 3 3 tricarboxylate 1 1 dibenzyl 1 1 2 2 5 5 6 6 octahydro 3 3 bipyridine 1 benzyl 4 hydroxypiperidin 3 yl methyl acetate 3 oxa 9 aza bicyclo 3 3 1 nonan 7 one hydrochloride 1 tert butyl 4 ethyl 4 methyl 3 oxopiperidine 1 4 dicarboxylate 4 bromo 1 propyl 1 2 3 6 tetrahydropyridine hydrochloride 6 BROMO 2 CHLORO 3 METHYL 4 4 4 5 5 TETRAMETHYL 1 3 2 DIOXABOROLAN 2 YL PYRIDINE 2 6 DICHLORO 3 METHYL 4 4 4 5 5 TETRAMETHYL 1 3 2 DIOXABOROLAN 2 YL PYRIDINE 3 FLUOROPYRIDINE 4 BORONIC ACID HYDRATE 2 3 DIMETHOXYPYRIDINE 4 BORONIC ACID 3 5 DIMETHYLPYRIDINE 4 BORONIC ACID PINACOL ESTER 3 BROMO 2 METHOXYPYRIDINE 4 BORONIC ACID 3 PICOLINE 4 BORONIC ACID HCL

2 ETHOXYPYRIDINE 4 BORONIC ACID 3 FLUORO 5 METHYLPYRIDINE 4 BORONIC ACID 3 CHLORO 2 METHOXYPYRIDINE 4 BORONIC ACID PINACOL ESTER 3 BROMO 2 FLUOROPYRIDINE 4 BORONIC ACID PINACOL ESTER 5 BROMO 2 ETHOXYPYRIDINE 4 BORONIC ACID 3 BROMO 5 METHOXY 4 PYRIDINYL BORONIC ACID 5 pentylpicolinic acid 4 4 4 5 5 TETRAMETHYL 1 3 2 DIOXABOROLAN 2 YL 2 6 PYRIDINEDICARBOXYLIC ACID 2 6 DIMETHYL ESTER 2 3 FLUOROPHENYL PYRIDINE 4 BORONIC ACID PINACOL ESTER 2 FLUORO 5 METHYLPYRIDINE 4 BORONIC ACID PINACOL ESTER 2 AMINO 4 PYRIDYL BORONIC ACID 3 CYANOPYRIDINE 4 BORONIC ACID PINACOL ESTER 2 CHLORO 3 CYANOPYRIDINE 4 BORONIC ACID 3 CYANOPYRIDINE 4 BORONIC ACID 2 PICOLINE 4 BORONIC ACID HCL 2 ETHOXYCARBONYL PYRIDIN 4 YL BORONIC ACID 3 CHLORO 4 5 5 DIMETHYL 1 3 2 DIOXABORINAN 2 YL PYRIDINE 5 6 7 8 tetrahydroimidazo 1 2 a pyrazine 2 carboxylic acid 1 ETHYL 4 TERT BUTYLOXYCARBONYL PIPERAZIN 2 ONE 3 CHLORO 2 4 MORPHOLINO PYRIDINE 4 BORONIC ACID PINACOL ESTER 3 CHLORO 2 MORPHOLINOPYRIDINE 4 BORONIC ACID 2 PYRIDINECARBOXAMIDE N 2 CHLORO 4 PYRIDINYL 6 METHYL 4 4 4 5 5 TETRAMETHYL 1 3 2 DIOXABOROLAN 2 YL 2 METHYL 3 OXOPIPERAZINE HYDROCHLORIDE 4 4 Difluoro L prolinamide hydrochloride 1 benzyl 3 methylpyrrolidin 3 ol 3 ACETAMIDOPYRROLIDINE 3 methylpyrrolidin 3 ol hydrochloride 1 tert butyl 2 methyl 2 ethyl 4 oxopyrrolidine 1 2 dicarboxylate 1S tert butyl 6 oxo 5 oxa 2 aza bicyclo 2 2 1 heptane 2 carboxylate 7 3 TRIFLUOROMETHYL PHENYL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBOXAMIDE

5 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDIN 2 AMINE 5 METHYLPYRAZOLO 1 5 A PYRIMIDIN 7 OL 6 2 CARBOXYBIPHENYL 4 YL METHYL 7 HYDROXY 5 PROPYLPYRAZOLO 1 5 A PYRIMIDINE 1 2 4 CHLOROPHENYL 7 METHYLPYRAZOLO 1 5 A PYRIMIDIN 6 YL ETHAN 1 ONE 2 TERT BUTYL 7 CHLORO 5 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 5 7 BIS TRIFLUOROMETHYL 2 METHYLTHIO PYRAZOLO 1 5 A PYRIMIDINE 3 CARBOXAMIDE 5 7 BIS TRIFLUOROMETHYL 3 CYANOPYRAZOLO 1 5 A PYRIMIDINE 5 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 2 3 DIAMINE 6 4 METHOXY PHENYL 3 PHENYL PYRAZOLO 1 5 A PYRIMIDINE 5 METHYLPYRAZOLO 1 5 A PYRIMIDIN 7 AMINE 2 4 BROMOPHENYL 5 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 6 BROMO PYRAZOLO 1 5 A PYRIMIDINE 2 CARBOXYLIC ACID 7 AMINO 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 5 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 5 1 METHYL CYCLOPROPYL 7 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 2 CARBOXYLIC ACID 5 ISOPROPYL 7 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 2 CARBOXYLIC ACID 6 BROMO 3 CHLOROPYRAZOLO 1 5 A PYRIMIDINE 2 CARBOXYLIC ACID 6 NITROPYRAZOLO 1 5 A PYRIMIDINE 6 TERT BUTYLSULFONYL 2 METHYLPYRAZOLO 1 5 A PYRIMIDIN 7 AMINE 7 CHLORO 5 6 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 5 METHYL 3 PHENYL PYRAZOLO 1 5 A PYRIMIDIN 7 YL HYDRAZINE 6 METHYLPYRAZOLO 1 5 A PYRIMIDINE 5 METHYLPYRAZOLO 1 5 A PYRIMIDINE 2 TERT BUTYL 7 CHLORO 3 IODO 5 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 5 HYDROXY 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 7 METHOXY 2 5 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2 5 7 TRIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2 METHYL 7 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 2 TERT BUTYL 7 HYDRAZINO 5 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 2 METHOXYMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID

7 HYDROXY 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 4 2 PHENYL 5 7 BIS TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDIN 3 YL PHENOL 2 PHENYL PYRAZOLO 1 5 A PYRIMIDIN 5 OL 7 PYRIDIN 3 YL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 6 BROMO 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 5 METHYL 2 PHENYL PYRAZOLO 1 5 A PYRIMIDIN 7 OL 7 AMINOPYRAZOLO 1 5 A PYRIMIDINE 6 CARBONITRILE 3 2 4 DIMETHYLAMINO PHENYL PYRAZOLO 1 5 A PYRIMIDIN 6 YL PROPAN 1 OL 7 FURAN 2 YL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 6 METHYL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBOXYLIC ACID 1 2 3 5 6 7 HEXAHYDRO 4 8A 9 TRIAZA CYCLOPENTA A S INDACEN 8 YLAMINE 3 3 4 DIETHOXY PHENYL 6 4 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 6 4 METHOXY PHENYL 3 THIOPHEN 2 YL PYRAZOLO 1 5 A PYRIMIDINE 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 5 7 DIOL 5 7 DICHLORO 3 METHYLPYRAZOLO 1 5 A PYRIMIDINE 3 4 FLUOROPHENYL 2 7 DIMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 1 quinolin 2 yl ethanone 4 bromo 2 methoxythiazole 5 bromo 2 methoxythiazole 4 bromo 2 isopropylthiazole 2 4 chlorophenylamino 4 9 dioxo 4 9 dihydronaphtho 2 3 b thiophene 3 carboxylic acid 1R 4aR 4bS 10aR methyl 2 4b 8 8 10a pentamethyl 1 4 4a 4b 5 6 7 8 8a 9 10 10a dodecahydrophenanthrene 1 carboxylate 6 hydroxy 9H purine 3 N oxide 6E 10E tricosa 6 10 dien 1 ol 2 chloro N 2 chloroethyl N cyclopropylmethyl ethanamine hydrochloride 2 2 2 diethoxyethoxy 1 1 diethoxyethane 3 4 4 5 5 tetramethyl 1 3 2 dioxaborolan 2 yl cyclopentanone 5 6 7 trimethoxy 2 phenylquinolin 4 1H one 2 2 4 dimethylphenyl 1 2 dihydropyrazol 3 one 1 2 4 dimethylphenyl 2 3 methoxyphenyl diazene