1 BOC 4 ISOPROPYLPIPERAZINE 1 BENZYL 4 3 NITROPYRIDIN 2 YL PIPERAZINE 1 tert butyl 2 methyl 2 3 chloropropyl pyrrolidine 1 2 dicarboxylate 1 benzylpyrrolidine 3 carbonitrile oxalate 1 1 ADAMANTYLCARBONYL PYRROLIDINE 2 CARBOXYLIC ACID 1 benzyl 3 methylpyrrolidin 3 amine 1 1 9H fluoren 9 yl methoxy carbonyl pyrrolidine 2 carbonyl pyrrolidine 2 carboxylic acid 3 benzyl 7 tert butyl 9 oxo 3 7 diaza bicyclo 3 3 1 nonane 3 7 dicarboxylate 2 4 tert butoxycarbonyl 2 methylpiperazin 1 yl acetic acid 4 benzylpiperazin 1 amine 2 CARBOXYMETHYL 3 OXO PIPERAZINE 1 CARBOXYLIC ACID TERT BUTYL ESTER 4 BENZYL 3 OXOPIPERAZINE 1 CARBOXYLIC ACID TERT BUTYL ESTER 5 hydroxymethyl 1 methylpyrrolidin 2 one 1 tert butyl 3 ethyl 3 methyl 4 oxopyrrolidine 1 3 dicarboxylate 3 benzyl 6 oxa 3 aza bicyclo 3 1 0 hexane 3 pyridin 4 yl 1H pyrazol 5 amine 2 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 5 CARBOXYLIC ACID 3 CHLORO 6 METHYLPYRAZOLO 1 5 A PYRIMIDINE 2 CARBOXYLIC ACID 5 BUTYL 6 2 1H TETRAZOL 5 YL 1 1 BIPHENYL 4 YL METHYL PYRAZOLO 1 5 A PYRIMIDIN 7 OL 7 CHLORO 5 METHYLPYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 1 2 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDIN 6 YL ETHAN 1 ONE 4 7 HYDROXY 5 PROPYLPYRAZOLO 1 5 A PYRIMIDIN 6 YL METHYL 1 1 BIPHENYL 2 CARBOXAMIDE 4 2 5 DIMETHYLPYRAZOLO 1 5 A PYRIMIDIN 7 YL AMINO 4 OXOBUTANOIC ACI D 7 2 PYRIDINYL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 5 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDIN 2 OL 6 4 METHOXY PHENYL 3 PYRIDIN 3 YL PYRAZOLO 1 5 A PYRIMIDINE 1 2 METHYLPYRAZOLO 1 5 A PYRIMIDIN 6 YL PROPAN 2 ONE 2 7 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 5 7 BIS TRIFLUOROMETHYL 3 CYANO 2 METHYLTHIO PYRAZOLO 1 5 A PYRIMIDINE 6 BROMO PYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE

2 5 DIMETHYL 6 PHENYLPYRAZOLO 1 5 A PYRIMIDIN 7 AMINE 9 TRIFLUOROMETHYL 5 6 7 8 TETRAHYDRO PYRAZOLO 5 1 B QUINAZOLINE 2 CARBOXYLIC ACID 5 6 DIMETHYLPYRAZOLO 1 5 A PYRIMIDIN 7 OL 5 CYCLOPROPYL 7 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 2 CARBOXYLIC ACID 3 BROMO 7 METHYLPYRAZOLO 1 5 A PYRIMIDINE 3 BROMO 5 6 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 5 6 DIMETHYLPYRAZOLO 1 5 A PYRIMIDINE 3 BROMO 2 TERT BUTYL 7 CHLORO 5 TRIFLUOROMETHYL PYRAZOLO 1 5 A PYRIMIDINE 2 PHENYL PYRAZOLO 1 5 A PYRIMIDINE 5 7 DIOL 2 HYDROXYMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 7 METHOXY 5 METHYL 2 PHENYLPYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 5 IODOPYRAZOLO 1 5 A PYRIMIDINE 5 7 DICHLORO 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 7 CHLORO 3 PHENYL PYRAZOLO 1 5 A PYRIMIDINE 6 NITROPYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 2 METHYLPYRAZOLO 1 5 A PYRIMIDINE 2 7 DIMETHYL 3 PHENYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 6 ACETYL 7 METHYLPYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 3 THIOPHEN 2 YL 6 3 4 5 TRIMETHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 6 METHYLPYRAZOLO 1 5 A PYRIMIDIN 7 OL 2 3 METHOXY PHENYL 6 4 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 3 3 THIOPHEN 2 YL PYRAZOLO 1 5 A PYRIMIDIN 6 YL PROPAN 1 OL 3 2 2 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDIN 6 YL PROPAN 1 OL 2 2 METHOXY PHENYL 6 4 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 7 HYDROXY 5 METHYLPYRAZOLO 1 5 A PYRIMIDINE 3 CARBONITRILE 6 4 METHOXY PHENYL 2 PHENYL PYRAZOLO 1 5 A PYRIMIDINE 2 3 BROMO PHENYL 6 4 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 3 PHENYL 6 3 4 5 TRIMETHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDINE 4 6 4 METHOXY PHENYL PYRAZOLO 1 5 A PYRIMIDIN 2 YL PHENYL DIMETHYL AMINE 5 7 DIMETHYL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBOXYLIC ACID

2 2 METHYLPYRAZOLO 1 5 A PYRIMIDIN 6 YL ACETIC ACID 3 4 METHOXYPHENYL 2 7 DIMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 3 3 CHLOROPHENYL 2 7 DIMETHYL PYRAZOLO 1 5 A PYRIMIDINE 6 CARBOXYLIC ACID 3 METHYLPYRAZOLO 1 5 A PYRIMIDINE 5 7 DIOL 2 METHYL PYRAZOLO 1 5 A PYRIMIDINE 3 CARBOXYLIC ACID 6 methylmorpholin 3 one 2 methylmorpholin 3 one 5 S 5 methyl 2 phenylthio dihydrofuran 2 3H one 5 6 DIHYDRO 4 METHOXY 2H PYRAN 7 methoxy 7 oxoheptanoic acid 2 3 4 dimethoxyphenyl 3 hydroxy 8 methyl 4H chromen 4 one 1 3 tert butyl 5 iodo 4 methoxyphenyl pyrimidine 2 4 1H 3H dione 1 2 4 dimethylphenyl 3 phenyl 1H pyrazole 5 4H one 2 3 4 dimethoxyphenyl 3 hydroxy 7 methoxyquinolin 4 1H one 3 3 4 dimethoxyphenyl 1 2 hydroxy 3 methylphenyl prop 2 en 1 one 4 4 methoxyquinolin 2 yl benzene 1 2 diol 2 3 4 dihydroxyphenyl 6 ethyl 3 hydroxy 4H chromen 4 one 1 2 4 dimethylphenyl 3 3 methoxyphenyl 1H pyrazol 5 4H one 4 4 1E 1 E 2 2 1 phenyl 1H pyrazole 3 5 diyl bis ethene 2 1 diyl diphenol 2 3 4 dimethoxyphenyl 3 hydroxyquinolin 4 2H one 2R 4S 1 benzyl 2 Methyl 4 hydroxypyrrolidine 1 2 dicarboxylate 2S 4R 1 benzyl 2 Methyl 4 hydroxypyrrolidine 1 2 dicarboxylate 1 benzyl 3 3 difluoropiperidin 4 one hydrochloride 4 1 Methylpiperidin 4 yl oxy aniline 3 TRIFLUOROMETHOXY PIPERIDINE 3 Fluoro 2 iodoaniline 3 Ethynyl 5 trifluoromethyl pyridine 2 2 2 Trifluoro 1 3 methoxypyridin 4 yl ethanone 2 1 tert butoxycarbonyl piperidin 4 yl 2 methylpropanoic acid 2 4 6 fluoroquinolin 4 yl cyclohexyl acetic acid

2 trifluoromethyl 4 methylsulfonyl phenyl methanol 1 benzyl 3 3 difluoropiperidine 4 4 diol 4 ethoxycarbonyl methyl cyclohex 1 enyl trifluoromethanesulfonate 3 3 difluoro 1 methylpiperidin 4 ol hydrochloride 5 5 5 trifluoro 4 4 dihydroxypentanoic acid 5 5 difluoro N S 3 1S 3R 5R 3 3 isopropyl 5 methyl 4H 1 2 4 triazol 4 yl 8 aza bicyclo 3 2 1 octan 8 yl 1 phenylpropyl 1 methylpiperidine 3 carboxamide 5 5 difluoro N S 3 1S 3R 5R 3 3 isopropyl 5 methyl 4H 1 2 4 triazol 4 yl 8 aza bicyclo 3 2 1 octan 8 yl 1 phenylpropyl 1 methylpiperidine 2 carboxamide 5 5 difluoro N S 3 1S 3R 5R 3 3 isopropyl 5 methyl 4H 1 2 4 triazol 4 yl 8 aza bicyclo 3 2 1 octan 8 yl 1 phenylpropyl piperidine 2 carboxamide 3 3 difluoro N S 3 1S 3R 5R 3 3 isopropyl 5 methyl 4H 1 2 4 triazol 4 yl 8 aza bicyclo 3 2 1 octan 8 yl 1 phenylpropyl 1 methylpiperidine 4 carboxamide 5 Bromo 2 methylpyridin 3 ol 2 3 Aminophenyl 2 methylpropanenitrile 4 Morpholin 4 yl benzene 1 carboximidamide hydrochloride 2 Chloromethyl nicotinonitrile 2 3 Fluoro 5 methoxyphenyl acetonitrile 3 2H 1 2 3 Trizazol 2 yl aniline 4 Bromo 1 bromomethyl 2 chlorobenzene 3 Amino 6 bromopyrazine 2 carbaldehyde 4 Aminobicyclo 2 2 2 octane 1 carboxylic acid methyl ester 4 Bromobutan 1 amine hydrobromide 4 Hydroxy 4 trifluoromethyl cyclohexanecarboxylic acid 4 tert Butyl cyclohex 1 ene 1 2 Bromo 5 chlorophenyl ethanone 5 Bromo 2 cyano 4 methylpyridine 3 3 Nitrophenoxy azetidine hydrochloride 5 Pyrimidinecarboxylic acid 4 6 dichloro ethyl ester 4 Chloro 8 fluoro 2 trifluoromethyl quinazoline 4 6 Dichloro 2 methylthio 5 nitropyrimidine 4 4 Ethylpiperazin 1 ylmethyl benzoic acid 4 Dimethylamino benzamide 4R 5R 3 tert Butyl 4 methyl 2 2 5 trimethyloxazolidine 3 4 dicarboxylate